Gene Name |
CIAPIN1 |
English Name |
cytokine induced apoptosis inhibitor 1 |
Chinese Name |
细胞因子诱导凋亡抑制因子1 |
Uniprot |
Q6FI81 |
GeneID |
57019 |
Predicted Cross Reactivity |
Human Mouse Rat (Bovine Zebrafish Fruit fly Chicken) |
氨基酸大小 |
34kDa |
表达氨基酸 |
1-312aa |
Background |
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors.This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus.It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues.Mutations in this gene are associated with generalized glucocorticoid resistance.Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |