Gene Name |
APP |
Synonyms |
A4,AAA,ABETA,ABPP,AD1,AICD 50,AICD 57,AICD 59,AID(50),AID(57),AID(59),Amyloid beta A4 protein,amyloid P,APP,APPI,beta Amyloid,CTFgamma,CVAP,Gamma CTF(50) C31,PN II,PN2,PreA4,Protease nexin II,S APP alpha Soluble APP beta |
English Name |
Recombinant human APP protein |
Full Name |
amyloid beta (A4) precursor protein |
Chinese Name |
β-淀粉样蛋白(A4)前体蛋白 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P05067 |
Gene ID |
351 |
Reactivity |
Human Mouse Rat (Pig Dog Sheep Monkey Fruit fly A.thaliana) |
Molecular Weight |
34kDa |
Interval Range |
1-306aa |
Background |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease.In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities.Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Multiple transcript variants encoding several different isoforms have been found for this gene. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 100ug 50ug 1mg |