Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > AZ-960

AZ-960

Manual Download

Cat.No：IA4480 Solarbio

CAS：905586-69-8

Molecular Formula：C₁₈H₁₆F₂N₆

Molecular Weight：354.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	905586-69-8
Name	AZ-960
Molecular Formula	C₁₈H₁₆F₂N₆
Molecular Weight	354.36
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16621127
SMILES	CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F
Target Point	JAK
Passage	JAK/STAT Signaling
Background	AZ960 is a potent and selective JAK2 kinase inhibitor.
Biological Activity	AZ960是高效选择性的JAK2激酶抑制剂，Ki值为0.45 nM。[1-4]
IC50	JAK2:0.45nM(Ki);JAK2:<3nM;JAK3:9nM [1-4]
Data Literature Source	[1]. Ikezoe T，et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129(10):2512-21. [2]. Yang J，et al. AZ960，a novel Jak2 inhibitor，induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9(12):3386-95. [3]. Valenciano AL，et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24(19):4647-51. [4]. Gozgit JM，et al. Effects of the JAK2 inhibitor，AZ960，on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.