{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > DisulfiramCAS：97-77-8
Molecular Formula：C10H20N2S4
Molecular Weight：296.54
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 97-77-8 |
| Name | Disulfiram |
| Molecular Formula | C10H20N2S4 |
| Molecular Weight | 296.54 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 202-607-8 |
| MDL | MFCD00009048 |
| SMILES | S=C(SSC(N(CC)CC)=S)N(CC)CC |
| InChIKey | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
| PubChem CID | 3117 |
| Target Point | Aldehyde Dehydrogenase (ALDH) |
| Passage | Metabolic Enzyme&Protease |
| Background | Disulfiram is a specific aldehyde dehydrogenase type 1 antibody (ALDH1) inhibitor. |
| Biological Activity | Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[1-5]. |
| Data Literature Source | [1]. Chen D，ert al. Disulfiram，a clinically used anti-alcoholism drug and copper-binding agent，induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res. 2006 Nov 1;66(21):10425-33. [2]. Wang W，et al. Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer. 2003 Apr 20;104(4):504-11. [3]. Cen D，et al. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J Med Chem. 2004 Dec 30;47(27):6914-20. [4]. Brar SS，et al. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro，in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004 Sep;3 [5]. Jun Jacob Hu，et al. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. The Preprint Server For Biology，2018，Jul. 10. |
| Unit | Bottle |
| Specification | 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
An Intrinsically Nontrimerizing Peptide Probe for Specifically Targeting Pathological Collagen in Connective Tissues
Click to check >>Author：Cai Xiangdong;Wei Wenyu;Bi Yihui; Liu Zhao;Bai Zh
IF：17.0930
Publish_to：Advanced Functional Materials
PMID：
Manual Download
