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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > FedratinibCAS：936091-26-8
Molecular Formula：C27H36N6O3S
Molecular Weight：524.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 936091-26-8 |
| Name | Fedratinib |
| Molecular Formula | C27H36N6O3S |
| Molecular Weight | 524.68 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD05863737 |
| SMILES | O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O |
| Target Point | JAK2，FLT3，RET |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;JAK/STAT Signaling |
| Background | Fedratinib is a selective inhibitor of JAK2. |
| Biological Activity | Fedratinib (TG-101348) 是 JAK2 的选择性抑制剂， IC50为3 nM，比对JAK1和JAK3的选择性高35，334倍。[1-4] |
| IC50 | JAK2:3nM;JAK2(V617F):3nM;Flt3:15nM;Ret:48nM [1-4] |
| Data Literature Source | [1]. Wernig G，et al. Efficacy of TG101348，a selective JAK2 inhibitor，in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20. [2]. Geron I，et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr;13(4):321-30. [3]. Lasho T，et al. Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells. Leukemia. 2010 Jul;24(7):1378-80. [4]. Mu CF，et al. Codelivery of Ponatinib and SAR302503 by Active Bone-Targeted Polymeric Micelles for the Treatment of Therapy-Resistant Chronic Myeloid Leukemia. Mol Pharm. 2017 Jan 3;14(1):274-283. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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