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Ruxolitinib Phosphate

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Cat.No：IR1000 Solarbio

CAS：1092939-17-7

Molecular Formula：C₁₇H₁₈N₆·H₃PO₄

Molecular Weight：404.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1092939-17-7
Name	Ruxolitinib Phosphate
Molecular Formula	C₁₇H₁₈N₆·H₃PO₄
Molecular Weight	404.36
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00083542
SMILES	N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2.O=P(O)(O)O
Target Point	JAK
Passage	JAK/STAT Signaling
Background	Ruxolitinib Phosphate is a potent JAK1/2 inhibitor.
Biological Activity	Ruxolitinib phosphate是一种有效的 JAK1/2 抑制剂， IC50 分别为3.3 nM/2.8 nM，比JAK3选择性高130倍。[1-3]
IC50	JAK2:2.8nM;JAK1:3.3nM;Tyk2:19nM;JAK3:428nM [1-3]
Data Literature Source	[1]. Quintas-Cardama A，et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood，2010，115(15)，3109-3117. [2]. Fleischman AG，et al. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21;122(22):3628-31. [3]. de Bock CE，et al. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018 May;8(5):616-631.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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