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My Cart> Cell Biology > Cell Detection > Cell Growth Factor > Recombinant Human KRAS(G12S)
Purity：≥95% as determined by reducing SDS-PAGE.
Storage：Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
Appearance：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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| Appearance | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Purity | ≥95% as determined by reducing SDS-PAGE. |
| Storage | Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months. |
| Background | K-Ras belongs to the small GTPase superfamily，Ras family.As other members of the Ras family，K-Ras is a GTPase and is an early player in many signal transduction pathways.It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus.K-Ras functions as a molecular on/off switch.Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.Plays an important role in the regulation of cell proliferation.Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.Besides essential function in normal tissue signaling，the mutation of a K-Ras gene is an essential step in the development of many cancers.Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome.Somatic K-Ras mutations are found at high rates in Leukemias，colon cancer，pancreatic cancer and lung cancer. |
| Source | E.coli |
| Solvent | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| Unit | Piece |
| Specification | 10ug 50ug 500ug 1mg |
Cell growth factor
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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