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AmLexanox

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Cat.No：IA4170 Solarbio

CAS：68302-57-8

Molecular Formula：C₁₆H₁₄N₂O₄

Molecular Weight：298.29

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	68302-57-8
Name	AmLexanox
Molecular Formula	C₁₆H₁₄N₂O₄
Molecular Weight	298.29
Solubility	Soluble in DMSO ≥5mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 804-135-3
MDL	MFCD00864790
SMILES	O=C(C1=C(N)N=C2C(C(C3=CC(C(C)C)=CC=C3O2)=O)=C1)O
InChIKey	SGRYPYWGNKJSDL-UHFFFAOYSA-N
InChI	InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
PubChem CID	2161
Target Point	TBK1，IKK-ε
Passage	NF-κB
Background	AmLexanox is a specific IKKε and TBK1 inhibitor.
Biological Activity	AmLexanox 是特异性的 IKKε 和 TBK1 抑制剂，IC50 值为 1-2 μM。[1-3]
Data Literature Source	[1]. Reilly SM，et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21. [2]. Bell，J. AmLexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig，2005. 25(9): p. 555-66. [3]. Zhang Y，et al. AmLexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss. Sci Rep. 2015 Sep 4;5:13575
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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