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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Chelidonic AcidCAS：99-32-1
Molecular Formula：C7H4O6
Molecular Weight：184.1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 99-32-1 |
| Name | Chelidonic Acid |
| Molecular Formula | C7H4O6 |
| Molecular Weight | 184.1 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 202-749-0 |
| MDL | MFCD00006577 |
| SMILES | O=C(C1=CC(C=C(C(O)=O)O1)=O)O |
| InChIKey | PBAYDYUZOSNJGU-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12) |
| PubChem CID | 7431 |
| Target Point | NF-κB，Caspase1 |
| Passage | NF-κB |
| Background | Chelidonic Acid has the potential to inhibit IL-6 production by blocking NF-κB and caspase-1. It is also a glutamate decarboxylase inhibitor. |
| Biological Activity | Chelidonic acid 是从 Chelidonium majus L. 中分到的酸类物质，为一种温和镇痛剂、抗菌剂和中枢神经系统镇静剂。Chelidonic acid 具有抗炎作用，可能通过抑制 NF-κB 和 caspase-1 来降低 IL-6 的产生。Chelidonic acid 为 glutamate decarboxylase 抑制剂，Ki 值为 1.2 μM。[1-3] |
| Data Literature Source | [1]. Shin HJ，et al. Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Immunopharmacol Immunotoxicol. 2011 Dec;33(4):614-9. [2]. Porter TG，et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50. [3]. Oh HA，et al. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Send to Int Immunopharmacol. 2011 Jan;11(1):39-45. |
| Unit | Bottle |
| Specification | 50mg 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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