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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > SB-225002CAS：182498-32-4
Molecular Formula：C13H10BrN3O4
Molecular Weight：352.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 182498-32-4 |
| Name | SB-225002 |
| Molecular Formula | C13H10BrN3O4 |
| Molecular Weight | 352.14 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00078305 |
| SMILES | O=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br |
| Target Point | CXCR |
| Passage | Immunology & Inflammation;GPCR & G Protein |
| Background | SB-225002 is a potent and selective CXCR2 non-peptide antagonist. |
| Biological Activity | SB225002 是一种有效的选择性 CXCR2 拮抗剂，IC50 为 22 nM。[1-5] |
| Data Literature Source | [1]. White JR，et al. Identification of a potent，selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8. [2]. Wang B，et al. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006 Mar 15;66(6):3071-7. [3]. Herz J，et al. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice. Stroke. 2015 Oct;46(10):2916-25. [4]. Wang LY，et al. CXCL5 signaling is a shared pathway of neuroinflammation and blood-brain barrier injury contributing to white matter injury in the immature brain. J Neuroinflammation. 2016 Jan 6;13:6. [5]. Shi ZR，et al. Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis. J Autoimmun. 2018 May;89:30-40. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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