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Yangonin

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Cat.No：IY0110 Solarbio

CAS：500-62-9

Molecular Formula：C₁₅H₁₄O₄

Molecular Weight：258.27

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	500-62-9
Name	Yangonin
Molecular Formula	C₁₅H₁₄O₄
Molecular Weight	258.27
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00221733
SMILES	O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1
Target Point	Cannabinoid Receptor（CB1）
Passage	GPCR & G Protein;Neuronal Signaling
Background	Yangonin is a dienolide kavalactone with neuroprotective, neuromodulatory and antifungal activities. Has Cannabinoid Receptor (CB1) receptors and enhances the effect of GABA-A receptors.
Biological Activity	Yangonin 对人重组大麻素 CB1 受体具有高的亲和力，IC50 和 Ki 分别为 1.79±0.53 μM 和 0.72±0.21 μM。[1-3]
Data Literature Source	[1]. Ligresti A，et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9. [2]. Ma J，et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54. [3]. Wruck CJ，et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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