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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > RG2833CAS：1215493-56-3
Molecular Formula：C20H25N3O2
Molecular Weight：339.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1215493-56-3 |
| Name | RG2833 |
| Molecular Formula | C20H25N3O2 |
| Molecular Weight | 339.43 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00214336 |
| SMILES | O=C(NCCCCCC(NC1=CC=CC=C1N)=O)C2=CC=C(C)C=C2 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | RG2833 is an HDAC inhibitor that acts on HDAC1 and HDAC3. |
| Biological Activity | RG2833 是一种大脑渗透的 HDAC 抑制剂，抑制 HDAC1 和 HDAC3 的活性，IC50 值分别为 60 nM 和 50 nM。[1-3] |
| Data Literature Source | [1]. Rai M，et al. Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model. PLoS One. 2010，5(1)，e8825. [2]. Sandi C，et al. Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model. Neurobiol Dis. 2011，42(3)，496-505. [3]. Johnston TH，et al. RGFP109，a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study. Parkinsonism Relat Disord. 2013，19(2)，260-264 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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