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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > RicolinostatCAS：1316214-52-4
Molecular Formula：C24H27N5O3
Molecular Weight：433.5
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1316214-52-4 |
| Name | Ricolinostat |
| Molecular Formula | C24H27N5O3 |
| Molecular Weight | 433.5 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22666356 |
| SMILES | O=C(C1=CN=C(N(C2=CC=CC=C2)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Ricolinostat is a selective HDAC6 inhibitor. |
| Biological Activity | Ricolinostat (ACY-1215) 是一种有效，选择性的 HDAC6 抑制剂，IC50 为 5 nM。ACY-1215 也可抑制 HDAC1，HDAC2 和 HDAC3，IC50 分别为 58，48 和 51 nM。 |
| Data Literature Source | [1]. Santo L，et al. Preclinical activity，pharmacodynamic，and pharmacokinetic properties of a selective HDAC6 inhibitor，ACY-1215，in combination with bortezomib in multiple myeloma. Blood. 2012 Mar 15;119(11):2579-89. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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