CAS |
94749-08-3 |
Chinese Name |
昔美酸沙美特罗 |
English Name |
Salmeterol Xinafoate |
Synonym |
Arial;Salmetedur;GR 33343X xinafoate;沙美特罗昔萘酸酯 |
Purity |
≥98% |
Unit |
Bottle |
Molecular Formula |
C25H37NO4·C11H8O3 |
Molecular Weight |
603.75 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO≥5mg/ml |
MDL |
MFCD00897708 |
InChIKey |
XTZNCVSCVHTPAI-UHFFFAOYSA-N |
InChI |
InChI=1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14) |
PubChem CID |
56801 |
SMILES |
O=C(C1=CC=C2C=CC=CC2=C1O)O.OC3=C(CO)C=C(C(CNCCCCCCOCCCCC4=CC=CC=C4)O)C=C3 |
Description |
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist. |
Target Point |
Adrenergic Receptor |
Passage |
Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
IC50 |
Ki: 1.5 nM (WT β2AR)[2] |
Data Literature Source |
[1]. Sharma M, et al. Salmeterol; A Long Acting β2-Aderenergic Receptor Agonist Inhibits Macrophage Activation by Lipopolysaccharide From Porphyromonas Gingivalis. J Periodontol. 2017 Mar 3:1-17.
[2]. Isogaya M, et al. Identification of a key amino acid of the beta2-adrenergic receptor for high affinity binding of salmeterol. Mol Pharmacol. 1998 Oct;54(4):616-22.
[3]. Walker RJ, Anderson NM, Bahouth S, Silencing of insulin receptor substrate-1 increases cell death in retinal Müller cells. Mol Vis. 2012;18:271-9. Epub 2012 Feb 1.
[4]. Hu Z, et al. Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells. Cell Mol Immunol. 2012 May;9(3):267-75. |
Specification |
5mg 10mg |