{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > TacedinalineCAS：112522-64-2
Molecular Formula：C15H15N3O2
Molecular Weight：269.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 112522-64-2 |
| Name | Tacedinaline |
| Molecular Formula | C15H15N3O2 |
| Molecular Weight | 269.3 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD00866266 |
| SMILES | O=C(NC1=C(N)C=CC=C1)C2=CC=C(NC(C)=O)C=C2 |
| InChIKey | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20) |
| PubChem CID | 2746 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Tacedinaline is a selective type I HDAC inhibitor. |
| Biological Activity | CI-994 (Tacedinaline)是组蛋白脱乙酰酶(HDAC)的抑制剂，抑制重组HDAC 1, 2 and 3的 IC50 值分别为0.9, 0.9, 1.2 μM.[1-4] |
| Data Literature Source | [1]. Moradei OM，et al. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. [2]. Loprevite M，etal. In vitro study of CI-994，a histone deacetylase inhibitor，in non-small cell lung cancer cell lines. Oncol Res. 2005;15(1):39-48. [3]. LoRusso PM，et al. Preclinical antitumor activity of CI-994. Invest New Drugs. 1996;14(4):349-56. [4]. Graziano MJ，et al. Immunotoxicity of the anticancer drug CI-994 in rats: effects on lymphoid tissue. Arch Toxicol. 1999 Apr-May;73(3):168-74 |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
