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My CartCAS：5355-16-8
Molecular Formula：C13H16N4O2
Molecular Weight：260.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 5355-16-8 |
| Name | Diaveridine |
| Molecular Formula | C13H16N4O2 |
| Molecular Weight | 260.29 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 226-333-3 |
| MDL | MFCD00057349 |
| SMILES | NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1 |
| InChIKey | LDBTVAXGKYIFHO-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17) |
| PubChem CID | 21453 |
| Target Point | Parasite;DHFR |
| Passage | Anti-infection |
| Background | Diaveridine is a coccidiostatic compound with antiparasitic activity and is a dihydrofolate reductase (DHFR) inhibitor. |
| Biological Activity | Diaveridine (EGIS-5645) 是二氢叶酸还原酶 (DHFR) 的抑制剂，对于野生型 DHFR 的 Ki 值为 11.5 nM，Diaveridine 也是一种抗菌剂。[1-3] |
| Data Literature Source | [1]. Sirichaiwat C et al. Target guided synthesis of 5-benzyl-2，4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 47:345-54 (2004). [2]. Ono T，et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. [3]. Wang J，et al. Acute，mutagenicity，teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40(2):660-70 |
| Unit | Bottle |
| Specification | 250mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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