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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Fenspiride HydrochlorideCAS：5053/8/7
Molecular Formula：C15H20N2O2·HCl
Molecular Weight：296.79
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 5053/8/7 |
| Name | Fenspiride Hydrochloride |
| Molecular Formula | C15H20N2O2·HCl |
| Molecular Weight | 296.79 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 225-752-9 |
| MDL | MFCD00133315 |
| SMILES | O=C1OC2(CCN(CCC3=CC=CC=C3)CC2)CN1.[H]Cl |
| Target Point | Adrenergic Receptor，Histamine Receptor，PDE |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation;Metabolic Enzyme&Protease |
| Background | Fenspiride Hydrochloride is an adrenergic receptor and H1 receptor antagonist. |
| Biological Activity | Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1-3]. |
| Data Literature Source | [1]. Matuszewska A，et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Adv Clin Exp Med. 2019 Jun;28(6):771-776. [2]. Cortijo J，et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol. 1998 Jan 2;341(1):79-86. [3]. De Castro CM，et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol. 1995 Dec 29;294(2-3):669-76. |
| Unit | Bottle |
| Specification | 50mg 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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