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CAS	30299-08-2
Chinese Name	克利贝特
English Name	Clinofibrate
Synonym	S-8527;Lipoclin
Purity	≥98%
Unit	Bottle
Molecular Formula	C₂₈H₃₆O₆
Molecular Weight	468.58
Appearance	White to off-white solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥5mg/ml
MDL	MFCD00865769
EC	EINECS 1312995-182-4
InChIKey	BMOVQUBVGICXQN-UHFFFAOYSA-N
InChI	InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
PubChem CID	2787
SMILES	CCC(OC1=CC=C(C2(C3=CC=C(OC(CC)(C)C(O)=O)C=C3)CCCCC2)C=C1)(C)C(O)=O
Description	Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) (hydroxymethylglutaryl coenzyme A reductase), a lipid-lowering agent used to control high cholesterol and triglyceride levels in the blood.
Target Point	HMG-CoA Reductase (HMGCR)
Passage	Metabolic Enzyme&Protease
Data Literature Source	[1]. Okazaki M, et al. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In Vivo. 1994 Nov-Dec;8(6):1057-61. [2]. Shirai K, et al. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983;12(3):145-55. [3]. Suzuki K, et al. Effects of S-8527 (1,1-bis4'-(1"-carboxy'1"-methylpropoxy)-phenyl)-cyclohexane), a new hypolipidemic compound, on triglyceride metablolism in rats. Biochem Pharmacol. 1975 Jun 15;24(11-12):1203-7. [4]. Suzuki K, et al. Hypolipidemic effect of a new aryloxy compound, S-8527, in experimental animals. Jpn J Pharmacol. 1974 Jun;24(3):407-14.
Specification	5mg 10mg 25mg