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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AGI-5198CAS：1355326-35-0
Molecular Formula：C27H31FN4O2
Molecular Weight：462.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1355326-35-0 |
| Name | AGI-5198 |
| Molecular Formula | C27H31FN4O2 |
| Molecular Weight | 462.56 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 806-071-1 |
| MDL | MFCD24848688 |
| SMILES | CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C |
| Target Point | Isocitrate Dehydrogenase (IDH) |
| Passage | Metabolic Enzyme&Protease |
| Background | AGI-5198 is a potent and selective mutant IDH1R132H inhibitor. |
| Biological Activity | AGI-5198是有效和选择性的突变体 IDH1R132H 抑制剂，IC50 为0.07 μM。[1-2] |
| Data Literature Source | [1]. Rohle D，et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340(6132):626-30. [2]. Molenaar RJ，et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 2015 Nov 15;75(22):4790-802 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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