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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > DeltarasinCAS：1440898-61-2
Molecular Formula：C40H37N5O
Molecular Weight：603.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1440898-61-2 |
| Name | Deltarasin |
| Molecular Formula | C40H37N5O |
| Molecular Weight | 603.75 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1(C2=CC=C(OC[C@@H](N3C4=CC=CC=C4N=C3C5=CC=CC=C5)C6CCNCC6)C=C2)=NC7=CC=CC=C7N1CC8=CC=CC=C8 |
| Target Point | KRAS-PDEδ |
| Passage | Others |
| Background | Deltarasin is a small molecule inhibitor that inhibits the KRAS-PDEδ interaction. |
| Biological Activity | Deltarasin 是一种 KRAS-PDEδ 相互作用的抑制剂，能够与 PDEδ 结合，Kd 值为 38 nM。[1-2] |
| Data Literature Source | [1]. Zimmermann G，et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42. [2]. Agalioti T，et al. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205 |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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