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4-Amino-PGA
CAS:54-62-6
Appearance:Yellow powder
Storage:Store at -20℃，5 years
Purity:＞98%
A 4-amino derivative of folic acid, it is a folic acid antagonist. Aminopterin catalyzes the reduction of folate to tetrahydrofolate, and Aminopterin competitively inhibits dihydrofolate reductase (DHFR) with a Ki value of 3.7 pM. Aminopterin has anticancer and immunosuppressive activities. Aminopterin is used to study childhood leukemia.
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