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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K110618P-50ul	Inquiry	Inquiry	Inquiry	Inquiry
K110618P-100ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-ERBB3 Polyclonal Antibody
Chinese Name	v-erb-b2红细胞白血病白血病病毒致癌基因同源物3抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	IHC 1:25-100.
Target	ERBB3
Synonyms	ERBB3;ErbB-3;HER3;LCCS2;MDA-BF-1;c-erbB-3;c-erbB3;erbB3-S;p180-ErbB3;p45-sErbB3;p85-sErbB3
Background	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Swiss Prot	P21860
Gene ID	2065
Subcellular Location	Cytoplasm Cell membrane
Immunogen	Recombinant protein of human ERBB3
Public Immunogen Range	1-331aa
Calculated MW	20/36/77/142/148kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human Rat Mouse
Application	IHC