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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K110681P-50ul	Inquiry	Inquiry	Inquiry	Inquiry
K110681P-100ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-APH1A Polyclonal Antibody
Chinese Name	早老素γ分泌酶抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	IHC 1:50-200.
Target	APH1A
Synonyms	Anterior Pharynx Defective 1, Anterior pharynx defective 1 homolog A, APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, Aph1a, APH1A_HUMAN, CGI 78, CGI78, Gamma secretase subunit APH 1A, Gamma Secretase Subunit APH1a, Gamma-secretase subunit APH-1A, Likely ortholog of C. elegans anterior pharynx defective 1A, Presenilin Stabilization Factor, Presenilin-stabilization factor, PSF, UNQ579/PRO1141
Background	This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
Swiss Prot	Q96BI3
Gene ID	51107
Subcellular Location	Cytoplasm
Immunogen	A synthetic peptide of human APH1A
Public Immunogen Range	215-265/265aa
Calculated MW	21/27/29kDa
Purification Method	Octanoic acid-ammonium sulfate precipitation
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human Mouse
Application	IHC