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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > 2-Methyl-6-(Phenylethynyl)Pyridine HydrochlorideCAS：96206-92-7
Molecular Formula：C14H11N
Molecular Weight：193.24
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 96206-92-7 |
| Name | 2-Methyl-6-(Phenylethynyl)Pyridine Hydrochloride |
| Molecular Formula | C14H11N |
| Molecular Weight | 193.24 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03787983 |
| SMILES | CC1=NC(C#CC2=CC=CC=C2)=CC=C1 |
| Target Point | mGluR |
| Passage | GPCR & G Protein |
| Background | It is a non-competitive antagonist of mGlu5 receptor and a positive allosteric modulator of mGlu4 receptor. |
| Biological Activity | MPEP is a potent， selective， noncompetitive， orally active and systemically active mGlu5 receptor antagonist， with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects[1-2]. |
| IC50 | mGluR5:36nM[1] |
| Data Literature Source | [1]. F Gasparini，et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP)，a Potent，Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503. [2]. E Tatarczyńska，et al. Potential anxiolytic- and antidepressant-like effects of MPEP，a potent，selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132(7):1423-30 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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