Gene Name |
TTR |
English Name |
transthyretin |
Chinese Name |
甲状腺素转运蛋白 |
Uniprot |
P02766 |
GeneID |
7276 |
Predicted Cross Reactivity |
Human Mouse (Bovine A.thaliana) |
氨基酸大小 |
16kDa |
表达氨基酸 |
1-147aa |
Background |
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid.The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein.The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis.Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic.The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Endotoxin |
/ |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |