Gene Name |
PDGFB |
English Name |
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) |
Chinese Name |
血小板衍生生长因子β多肽 |
Uniprot |
P01127 |
GeneID |
5155 |
Predicted Cross Reactivity |
Human Mouse Rat (Pig Cat Sheep) |
氨基酸大小 |
27kDa |
表达氨基酸 |
1-241aa |
Background |
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF).The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A.These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes.Mutations in this gene are associated with meningioma.Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor.Alternative splicing results in multiple transcript variants. |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Endotoxin |
/ |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |