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CAS:320-67-2
Appearance:White Powder
Storage:Store at RT，3 years
Purity:≥98.0%
Product introduction
Scientific research reagents, widely used in molecular biology, pharmacology and other scientific research. 5-azacytidine (5-azacytidine) is a potent hypomethylating growth inhibitor and cytotoxic agent that inhibits DNA methyltransferases. It is also a cell cycle-specific drug acting in S phase. It can rapidly phosphorylate and incorporate into RNA, inhibiting protein synthesis by disrupting the smooth translation of nucleic acids into proteins. It can also affect the synthesis of pyrimidine by inhibiting orotic acid nucleotide decarboxylase. It is an important regulator of gene expression, gene activation and silencing.
Application:
"This product is a nucleoside analogue capable of selectively activating eukaryotic gene expression and, under certain circumstances, altering the differentiation state of cells." It has powerful bacteriostatic, antitumor and mutagenic effects and is used as a chemotherapeutic agent in cancer for the treatment of solid tumors.5-azacytidine has been reported to significantly alter the differentiation state of mouse embryos and inhibit the methylation of newly synthesized DNA. This product has also been used to study the cell cycle activation of sex chromosomes and its effect on the expression of phenotypic traits in embryonic cells and individual animals and plants.
dissolution use:
can be dissolved in acetic acid aqueous solution (1:1 v/v) with a solubility of 5 mg/ml. It can also be dissolved in tissue culture medium (1.2 mg/10 ml), and the specific concentration can be diluted according to the experiment. It is not stable in aqueous solution and needs to be mixed and filtered to remove bacteria.
Azacitidine is a hypomethylating DNA methyltransferase inhibitor (DMT1).
It is a cell cycle-specific drug acting on S phase. It can rapidly phosphorylate and incorporate into RNA and DNA to inhibit protein synthesis by disrupting the smooth translation of nucleic acid into protein. It can also affect the synthesis of pyrimidine by inhibiting orotic acid nucleotide decarboxylase.
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