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CAS:53-86-1
Appearance:White to yellow solid
Storage:Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Purity:≥98%
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Examples of using this product（for reference only）
In Vitro:
Cell（0.2 mM indomethacin）：
The adipogenic medium was the complete culture medium supplemented with 1 μM dexamethasone (Solarbio), 0.2 mM indomethacin (Solarbio), 0.01 g/L insulin (Solarbio), and 0.5 mM isobutyl-methylxanthine (Solarbio).
Reference：
Jia L, Zhang Y, Ji Y, Li X, Xing Y, Wen Y, Huang H, Xu X. Comparative analysis of lncRNA and mRNA expression profiles between periodontal ligament stem cells and gingival mesenchymal stem cells. Gene. 2019 May 30;699:155-164. doi: 10.1016/j.gene.2019.03.015. Epub 2019 Mar 12. PMID: 30876821.
In Vivo:
Rat（Male Sprague–Dawley rats (180–200 g)，10 mg/kg indomethacin，tail vein injected）：
In brief, after the rats were anesthetized, indomethacin (Solarbio Biological, Ltd, Beijing, China) (10 mg/kg) was injected into the tail vein and then L-NAME (10 mg/kg) and iohexol (3500 mg/kg) were injected 20 minutes later. Rats in the DDCM group were treated with dapagliflozin (5 mg/kg, dissolved in 2 mL of saline) 1 day and 30 minutes before the administration of contrast media, while rats in the control group received saline.
Reference：
Huang X, Guo X, Yan G, Zhang Y, Yao Y, Qiao Y, Wang D, Chen G, Zhang W, Tang C, Cao F. Dapagliflozin Attenuates Contrast-induced Acute Kidney Injury by Regulating the HIF-1α/HE4/NF-κB Pathway. J Cardiovasc Pharmacol. 2022 Jun 1;79(6):904-913. doi: 10.1097/FJC.0000000000001268. PMID: 35383661; PMCID: PMC9162274.
