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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Alendronate Sodium TrihydrateCAS：121268-17-5
Molecular Formula：C4H12NO7P2·3H2O·Na
Molecular Weight：325.13
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 121268-17-5 |
| Name | Alendronate Sodium Trihydrate |
| Molecular Formula | C4H12NO7P2·3H2O·Na |
| Molecular Weight | 325.13 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 601-766-4 |
| MDL | MFCD01748233 |
| SMILES | [O-]P(C(O)(CCCN)P(O)(O)=O)(O)=O.O.O.O.[Na+] |
| Target Point | farnesyl diphosphate synthase |
| Passage | Metabolic Enzyme&Protease |
| Background | Alendronate Sodium Trihydrate is a farnesyl diphosphate synthase inhibitor. |
| Biological Activity | Alendronate sodium hydrate 是一种 farnesyl diphosphate synthase 抑制剂，IC50 值为 460 nM。[1-5] |
| Data Literature Source | [1]. Fisher JE，et al. Alendronate mechanism of action: geranylgeraniol，an intermediate in the mevalonate pathway，prevents inhibition of osteoclast formation，bone resorption，and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. [2]. Bergstrom JD，et al. Alendronate is a specific，nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. [3]. Keller RK，et al. Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem Biophys Res Commun. 1999 Dec 20;266(2):560-3. [4]. Elliott SN，et al. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci. 1998;62(1):77-91. [5]. Stearns ME，et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis. 1996;16(3):116-31. |
| Unit | Bottle |
| Specification | 100mg 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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