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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AloxistatinCAS：88321-09-9
Molecular Formula：C17H30N2O5
Molecular Weight：342.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 88321-09-9 |
| Name | Aloxistatin |
| Molecular Formula | C17H30N2O5 |
| Molecular Weight | 342.43 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00132883 |
| SMILES | O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O)OCC |
| Target Point | Cysteine protease |
| Passage | Metabolic Enzyme&Protease |
| Background | It is an irreversible membrane permeable cysteine protease inhibitor with the activity of inhibiting platelet aggregation. |
| Biological Activity | Aloxistatin (E64d) 是可渗透细胞,不可逆的广谱半胱氨酸蛋白酶 (cysteine protease) 抑制剂。[1-5] |
| Data Literature Source | [1]. Doh-Ura K，et al. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol. 2000 May;74(10):4894-7. [2]. Konjar S，et al. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. [3]. Mullins SR，et al. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012 Dec;393(12):1405-16. [4]. Hook G，et al. The cysteine protease inhibitor，E64d，reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B，but not BACE1，β-secretase activity. J Alzheimers Dis. 2011;26(2):387-408. [5]. Cheng XW，et al. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug;173(2):358-69. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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