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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K110952P-50ul	Inquiry	Inquiry	Inquiry	Inquiry
K110952P-100ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-IPO4 Polyclonal Antibody
Chinese Name	进口蛋白4抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	WB 1:1000-3000. IHC 1:50-200.
Target	IPO4
Synonyms	Importin-4;Imp4;Importin-4b;Imp4b;RanBP4;IMP4B;RANBP4;
Background	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Swiss Prot	Q8TEX9
Gene ID	79711
Subcellular Location	Cytoplasm Nucleus
Immunogen	Recombinant protein of human IPO4
Public Immunogen Range	1-350aa
Calculated MW	119kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human Mouse
Application	WB IHC