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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-PELI1 Polyclonal Antibody
Chinese Name	E3泛素蛋白连接酶pellino同源物1抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	IHC 1:50-200.
Target	PELI1
Synonyms	PELI1,PRISM,E3 ubiquitin-protein ligase pellino homolog 1,Pellino-1,EC 2.3.2.27,Pellino-related intracellular-signaling molecule,RING-type E3 ubiquitin transferase pellino homolog 1
Background	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
Swiss Prot	Q96FA3
Gene ID	57162
Subcellular Location	Nucleus Cytoplasm
Immunogen	Recombinant protein of human PELI1
Public Immunogen Range	1-350aa
Calculated MW	46kDa
Purification Method	Octanoic acid-ammonium sulfate precipitation
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Y-Dilution Ratio	IHC 1:50-200. ELISA 1:3000-30000.
Specification	50ul 100ul
Reactivity	Human Mouse
Application	IHC ELISA