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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BMS-687453CAS：1000998-59-3
Molecular Formula：C22H21ClN2O6
Molecular Weight：444.9
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1000998-59-3 |
| Name | BMS-687453 |
| Molecular Formula | C22H21ClN2O6 |
| Molecular Weight | 444.9 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251482 |
| SMILES | CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC |
| Target Point | PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | BMS-687453 is a potent and selective PPARα agonist. |
| Biological Activity | BMS-687453 is a potent and selective PPARα agonist， with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.[1-3] |
| Data Literature Source | [1]. Li J，et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53 [2]. Mukherjee R，et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides，raise high-density lipoprotein，and synergistically increase cholesterol excretion with a liver X receptor agonist. J Phar [3]. Vassallo JD，et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111(2):402-12. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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