Bisacodyl
Cat.No:IB1660 Solarbio
CAS:603-50-9
Molecular Formula:C22H19NO4
Molecular Weight:361.39
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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BisacodylCAS:603-50-9
Molecular Formula:C22H19NO4
Molecular Weight:361.39
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
Qty:
Size:
CAS | 603-50-9 |
Name | Bisacodyl |
Molecular Formula | C22H19NO4 |
Molecular Weight | 361.39 |
Solubility | Soluble in DMSO |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 210-044-4 |
MDL | MFCD00038039 |
SMILES | CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3 |
InChIKey | KHOITXIGCFIULA-UHFFFAOYSA-N |
InChI | InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3 |
PubChem CID | 2391 |
Target Point | Others |
Passage | Others |
Background | Bisacodyl is a stimulant laxative compound that acts primarily on the large intestine. Localized axonal and segmental reflexes can also be stimulated, resulting in extensive colonic peristalsis. |
Biological Activity | Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect[1]. |
Data Literature Source | [1]. Ikarashi,N.,et al.,The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol,2011. 301(5): p. G887-95. [2]. Saunders,D.R.,et al.,Effect of bisacodyl on the structure and function of rodent and human intestine. Gastroenterology,1977. 72(5 Pt 1): p. 849-56. [3]. Karmeli,F.,R. Stalnikowicz,and D. Rachmilewitz,Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity. Scand J Gastroenterol,1997. 32(8): p. 791-6. [4]. Rachmilewitz,D.,F. Karmeli,and E. Okon,Effects of bisacodyl on cAMP and prostaglandin E2 contents,(Na + K) ATPase,adenyl cyclase,and phosphodiesterase activities of rat intestine. Dig Dis Sci,1980. 25(8): p. 602-8. [5]. Borrelli,F.,et al.,Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon. Life Sci,2001. 69(16): p. 1871-7. |
Unit | Bottle |
Specification | 500mg 1g |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
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