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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > Bisindolylmaleimide IXCAS：138489-18-6
Molecular Formula：C25H23N5O2S·CH4O3S
Molecular Weight：553.65
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 138489-18-6 |
| Name | Bisindolylmaleimide IX |
| Molecular Formula | C25H23N5O2S·CH4O3S |
| Molecular Weight | 553.65 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00001197 |
| SMILES | NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O |
| Target Point | PKC |
| Passage | TGF-beta/Smad;Epigenetics |
| Background | Bisindolylmaleimide IX is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε, and also inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β. |
| Data Literature Source | [1]. Wilkinson SE，et al. Isoenzyme specificity of bisindolylmaleimides，selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 (Pt 2):335-7. [2]. Davies SP，et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [3]. Tian F，et al. Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology. 2007 Jul;28(4):843-9. Epub 2007 Apr 20. [4]. Hambleton M，et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation. 2006 Aug 8;114(6):574-82 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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