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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Cariprazine HydrochlorideCAS：1083076-69-0
Molecular Formula：C21H33Cl3N4O
Molecular Weight：463.87
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1083076-69-0 |
| Name | Cariprazine Hydrochloride |
| Molecular Formula | C21H33Cl3N4O |
| Molecular Weight | 463.87 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142670 |
| SMILES | O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C.[H]Cl |
| Target Point | Dopamine Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a partial agonist of dopamine D2/D3 receptor, which can be used in the related research of psychosis. |
| Biological Activity | Cariprazine hydrochloride is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors， and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).[1-5] |
| Data Literature Source | [1]. Seneca N， et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate， cariprazine (RGH-188)， in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 [2]. Kiss B， et al. Cariprazine (RGH-188)， a dopamine D(3) receptor-preferring， D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. [3]. Zimnisky R， et al. Cariprazine， a dopamine D(3)-receptor-preferring partial agonist， blocks phencyclidine-induced impairments of working memory， attention set-shifting， and recognition memory in the mouse. Psychopharmacology (Berl). 2013 Mar;226(1):91-100. [4]. Gao Y， et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073. [5]. Citrome L. Cariprazine in schizophrenia: clinical efficacy， tolerability， and place in therapy. Adv Ther. 2013 Feb;30(2):114-26. |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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