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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-BRSK1 Polyclonal Antibody
Chinese Name	丝氨酸/苏氨酸蛋白激酶SAD-B抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	IHC 1:50-200.
Target	BRSK1
Synonyms	BR serine/threonine kinase 1, BR serine/threonine protein kinase 1, BR serine/threonine-protein kinase 1, Brain-specific serine/threonine-protein kinase 1, BRSK 1, Brsk1, BRSK1_HUMAN, Protein kinase SAD1A, SAD 1, SAD1, SAD1 kinase, SAD1A, SADB, SadB kinase short isoform, Serine/threonine kinase SAD B,Serine/threonine-protein kinase SAD-B, Synapses of Amphids Defective homolog, FLJ43009, KIAA1811
Background	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Swiss Prot	Q8TDC3
Gene ID	84446
Subcellular Location	Cytoplasm Nucleus
Immunogen	A synthetic peptide of human BRSK1
Public Immunogen Range	460-510/778aa
Calculated MW	39/85/87kDa
Purification Method	Octanoic acid-ammonium sulfate precipitation
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human Rat Mouse
Application	IHC