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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Chelidamic AcidCAS：138-60-3
Molecular Formula：C7H5NO5
Molecular Weight：183.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow Solid
Qty：
Size：
| CAS | 138-60-3 |
| Name | Chelidamic Acid |
| Molecular Formula | C7H5NO5 |
| Molecular Weight | 183.12 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-335-8 |
| MDL | MFCD00066478 |
| SMILES | O=C(C1=CC(C=C(C(O)=O)N1)=O)O |
| InChIKey | XTLJJHGQACAZMS-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H5NO5/c9-3-1-4(6(10)11)8-5(2-3)7(12)13/h1-2H,(H,8,9)(H,10,11)(H,12,13) |
| PubChem CID | 8743 |
| Target Point | glutamate decarboxylase |
| Passage | Metabolic Enzyme&Protease |
| Background | Chelidamic acid is also a potent glutamate decarboxylase inhibitor. |
| Biological Activity | Chelidamic acid 是一种含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。Chelidamic acid 也是最有效的谷氨酸脱羧酶 (glutamate decarboxylase) 抑制剂之一，其 Ki 值为 33 μM。[1-3] |
| IC50 | Ki: 33μM(Glutamate decarboxylase)[3] |
| Data Literature Source | [1]. Searcey M，et al. Synthesis，DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. [2]. Espinet P，et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug，7;39(16):3645-51. [3]. Porter TG，et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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