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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > 7,8-Dihydroxy-4-methylcoumarinCAS：2107-77-9
Molecular Formula：C10H8O4
Molecular Weight：192.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to yellow Solid
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| CAS | 2107-77-9 |
| Name | 7,8-Dihydroxy-4-methylcoumarin |
| Molecular Formula | C10H8O4 |
| Molecular Weight | 192.17 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 218-290-4 |
| MDL | MFCD00016972 |
| SMILES | O=C1C=C(C)C2=CC=C(O)C(O)=C2O1 |
| Target Point | Others |
| Passage | Others |
| Background | 4-Methyldaphnetin is a precursor for the synthesis of 4-methylcoumarin derivatives. 4-Methyldaphnetin has potent and selective anti-proliferative and apoptosis-inducing effects on several tumor cell lines. 4-Methyldaphnetin has the effect of scavenging free radicals and has a strong inhibitory effect on membrane lipid peroxidation. |
| Biological Activity | 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent， selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1-3]. |
| Data Literature Source | [1]. Vázquez R，et al. Pharmacodynamic study of the 7，8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X，et al. 7，8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG，et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7，8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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