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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-BCAR3 Polyclonal Antibody
Chinese Name	乳腺癌抗雌激素抗性蛋白3抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	WB 1:1000-3000.;IHC 1:50-200.
Target	BCAR3
Synonyms	BCAR 3,BCAR3,BCAR3_HUMAN,Breast cancer anti estrogen resistance 3,Breast cancer anti estrogen resistance protein 3,Breast cancer anti-estrogen resistance protein 3,Breast cancer antiestrogen resistance 3,dJ1033H22.2,dJ1033H22.2 breast cancer anti estrogen resistance 3,dJ1033H22.2 breast cancer antiestrogen resistance 3,KIAA0554,Novel SH2 containing protein 2,Novel SH2-containing protein 2,NSP 2,NSP2,SH2 containing protein Nsp2,SH2 domain containing protein 3B,SH2 domain-containing protein 3B,SH2D3B
Background	Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014).
Swiss Prot	O75815
Gene ID	8412
Subcellular Location	Cytoplasm
Immunogen	A synthetic peptide of human BCAR3
Public Immunogen Range	430-480/825aa
Calculated MW	56/82/93kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Y-Dilution Ratio	WB 1:1000-3000. IHC 1:50-200.
Specification	50ul 100ul
Reactivity	Human
Application	IHC WB