English Name |
Anti-BIN1 Polyclonal Antibody |
Chinese Name |
Myc 盒依赖性相互作用蛋白 1抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:1000-3000. |
Target |
BIN1 |
Synonyms |
Amphiphysin like protein, AMPH 2, AMPH2, Amphiphysin 2, Amphiphysin II, Amphiphysin like protein, amphiphysin-like, AMPHL, Box Dependant MYC Interacting Protein 1, Bridging Integrator 1, DKFZp547F068, MGC10367, MGC105358, Myc box dependent interacting protein 1, SH3P9, BIN1_HUMAN |
Background |
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
Swiss Prot |
O00499 |
Gene ID |
274 |
Subcellular Location |
Cytoplasm |
Immunogen |
A synthetic peptide of human BIN1 |
Public Immunogen Range |
55-105/593aa |
Calculated MW |
46/47/48/50/52/53/55/56/60/65kDa |
Purification Method |
Octanoic acid-ammonium sulfate precipitation |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human |
Application |
WB |