| Product Type |
Peptides |
| CAS |
138764-85-9 |
| Sequence(1LC) |
YKQRVKNK-NH2 |
| Sequence(3LC) |
Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 |
| Synonyms |
PACAP-38(31-38)(human,chicken,mouse,ovine,porcine,rat);Pituitary Adenylate Cyclase Activating Peptide(31-38)(human,ovine,rat); |
| Molecular Formula |
C47H83N17O11 |
| Molecular Weight |
1062.29 |
| Purity |
≥95% |
| Appearance |
Lyophilized powder |
| Solubility |
H2O：100 mg/mL;
*Ultrasonic solubilization; |
| Salt Form |
Trifluoroacetate salt |
| Source |
Synthetic |
| Storage |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label |
Hormone and Related Peptides |
| Background |
PACAP-38 (31-38),human,mouse,rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38),human,mouse,rat elevates cytosolic Ca2+,increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38),human,mouse,rat demonstrates potent,efficacious,and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38),human,mouse,rat can be used for neurotrophic and neuroprotective research. |
| In Vitro |
PACAP-38 (31-38), human, mouse, rat (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2 and ERK tyrosine phosphorylation.
PACAP-38 (31-38), human, mouse, rat (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%.
PACAP-38 (31-38), human, mouse, rat (10 nM; 48 h) stimulates the growth of NCI-H838 cells.
PACAP-38 (31-38), human, mouse, rat (300 nM; 4 h) stimulates generation of APPsα in neural cells.
PACAP-38 (31-38), human, mouse, rat (0.01-10 nM; HEK 293 cells) stimulates neural cells express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM.
PACAP-38 (31-38), human, mouse, rat (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures.
PACAP-38 (31-38), human, mouse, rat (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons. |
| Reference |
[1] Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017;
[2] Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4;
[3] Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 Dec 26;805:204-16. |
| Unit |
Bottle |
| Specification |
1mg 5mg |
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