| Product Type |
Peptides |
| CAS |
208041-90-1 |
| Sequence(1LC) |
RSRTRQFYGLM-NH2 |
| Sequence(3LC) |
Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2 |
| Synonyms |
Hemokinin 1 (Mouse);HEK-1,Mouse;HEK-1 (Mouse,Rat)； |
| Molecular Formula |
C61H100N22O15S1 |
| Molecular Weight |
1413.67 |
| Purity |
≥95% |
| Appearance |
Lyophilized powder |
| Solubility |
DMSO：100 mg/mL;
*Ultrasonic solubilization; |
| Salt Form |
Trifluoroacetate salt |
| Source |
Synthetic |
| Storage |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label |
Neuropeptides and Related Peptides |
| Background |
Hemokinin 1 (HK-1) is encoded by the preprotachykinin C (PPT-C) gene, which could be identified in hematopoietic cells in mouse. The undecapeptide HK-1 is a full agonist of all known three tachykinin NK1, NK2, and NK3 receptors with a remarkable selectivity for the NK1 receptor. In in vivo experiments it acts with potency similar to substance P. |
| In Vitro |
Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB. |
| In Vivo |
Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats. |
| Reference |
[1] F.Bellucci et al., Br. J. Pharmacol., 135, 266(2002). |
| Unit |
Bottle |
| Specification |
1mg 5mg |
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