Product Type |
Peptides |
CAS |
149635-73-4 |
Sequence(1LC) |
MEVGWYRSPFSRVVHLYRNGK |
Sequence(3LC) |
Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys |
Synonyms |
MOG (35-55),(mouse,rat);MOG (35-55) |
Molecular Formula |
C118H177N35O29S1 |
Molecular Weight |
2581.98 |
Purity |
≥95% |
Appearance |
Lyophilized powder |
Solubility |
H2O:≥50 mg/mL; *Ultrasonic solubilization; |
Salt Form |
Trifluoroacetate salt |
Source |
Synthetic |
Storage |
Store at -20℃,2 years.(Avoid freeze/thaw cycles) |
Category/Label |
Neuropeptides and Related Peptides |
Background |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces strong T and B cell responses and is highly encephalitogenic. |
In Vitro |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) induces T cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat increases the level of IgG. |
In Vivo |
Myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 is one target of the autoreactive T cell response, leading to an acute and later chronic autoimmune process. MOG 35-55 is able to induce experimental autoimmune encephalomyelitis (EAE) in the B6 mouse. |
Reference |
[1] Slavin, A. et al. Autoimmunity 28, 109 (1998); [2] Ichikawa, M. et al. Cellular Immunol 19[1] 97 (1999); [3] Kennel De March, A. et al. J Neuroimmunol 135, 117 (2003); [4] Robinson, W. et al. Nat Biotech 21, 1033 (2003). |
Unit |
Bottle |
Specification |
1mg 5mg |