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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > SR1078CAS：1246525-60-9
Molecular Formula：C17H10F9NO2
Molecular Weight：431.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1246525-60-9 |
| Name | SR1078 |
| Molecular Formula | C17H10F9NO2 |
| Molecular Weight | 431.25 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18782737 |
| SMILES | O=C(NC1=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C1)C2=CC=C(C(F)(F)F)C=C2 |
| InChIKey | DUXWIYXHHGNUJU-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H10F9NO2/c18-15(19,20)11-3-1-9(2-4-11)13(28)27-12-7-5-10(6-8-12)14(29,16(21,22)23)17(24,25)26/h1-8,29H,(H,27,28) |
| PubChem CID | 17980288 |
| Target Point | RORα;RORγ |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a RORα/RORγ) agonist. |
| Biological Activity | SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors， leading to stimulation of RORα/γ target gene transcription.[1-2] |
| Data Literature Source | [1]. Wang Y， et al. Identification of SR1078， a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol. 2010 Nov 19;5(11):1029-34. [2]. Wang Y， Billon C， Walker JK， Burris TP. Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci. 2016;7(2):143-148. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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