{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > SL 0101-1CAS：77307-50-7
Molecular Formula：C25H24O12
Molecular Weight：516.45
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 77307-50-7 |
| Name | SL 0101-1 |
| Molecular Formula | C25H24O12 |
| Molecular Weight | 516.45 |
| Solubility | Soluble in --- |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD09842349 |
| SMILES | OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1 |
| InChIKey | SXOZSDJHGMAEGZ-IGKKHSBFSA-N |
| InChI | InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1 |
| PubChem CID | 10459196 |
| Target Point | Ribosomal S6 Kinase (RSK) |
| Passage | MAPK |
| Background | SL 0101-1 is a selective, reversible, ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK). |
| Biological Activity | SL 0101-1 (SL0101)， a kaempferol glycoside， isolated from the tropical plant F. refracta， is a cell-permeable， selective， reversible， ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor， with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor， with a Ki of 1 μM[2]. |
| IC50 | RSK1 |
| Data Literature Source | [1]. Smith JA，et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. [2]. Yu Li，et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
