CAS |
737-31-5 |
Chinese Name |
泛影酸钠 |
English Name |
Diatrizoate Sodium |
Synonyms |
Hypaque sodium;Triombrin Sodium;Sodium amidotrizoate |
Molecular Formula |
C11H8I3N2NaO4 |
Molecular Weight |
635.9 |
Solubility |
Soluble in Water/DMSO ≥10mg/mL |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
EC |
EINECS 212-004-1 |
MDL |
MFCD00051544 |
SMILES |
O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.[Na+] |
InChIKey |
ZEYOIOAKZLALAP-UHFFFAOYSA-M |
InChI |
InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1 |
PubChem CID |
23672589 |
Background |
It is an iodinated radiocontrast agent. |
Biological Activity |
Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium[1][2]. |
In Vitro |
HK-2 cells are exposed to 0-30 mg I/mL Sodium diatrizoate (Diatrizoic acid sodium salt) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively[2]. |
In Vivo |
Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1]. |
Data Literature Source |
[1]. El-Gendy N,et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12. [2]. Dakota B Ward,et al. Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation. Int J Mol Sci. 2019 Aug 21;20(17):4074. |
Unit |
Bottle |
Specification |
500mg 1g |