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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Disodium (R)-2-HydroxyglutarateCAS：103404-90-6
Molecular Formula：C5H6O5Na2
Molecular Weight：192.08
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 103404-90-6 |
| Name | Disodium (R)-2-Hydroxyglutarate |
| Molecular Formula | C5H6O5Na2 |
| Molecular Weight | 192.08 |
| Solubility | Soluble in Water ≥2mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00069573 |
| SMILES | O=C([O-])[C@H](O)CCC([O-])=O.[Na+].[Na+] |
| InChIKey | DZHFTEDSQFPDPP-HWYNEVGZSA-L |
| InChI | InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1 |
| PubChem CID | 51051608 |
| Target Point | α-ketoglutarate-dependent dioxygenases |
| Passage | Metabolic Enzyme&Protease |
| Background | D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1-5]. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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