| CAS |
138-14-7 |
| Chinese Name |
甲磺酸去铁胺 |
| English Name |
Deferoxamine Mesylate |
| Synonyms |
甲磺酸去铁胺;去铁胺甲磺酸盐;DEFEROX胺甲磺酸盐;甲磺酸除铁灵;去铁胺甲磺酸酯; |
| Molecular Formula |
C26H52N6O11S |
| Molecular Weight |
656.79 |
| Solubility |
Soluble in Water ≥20mg/mL |
| Purity |
≥92% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 205-314-3 |
| MDL |
MFCD00058605 |
| SMILES |
O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O.CS(=O)(O)=O |
| InChIKey |
IDDIJAWJANBQLJ-UHFFFAOYSA-N |
| InChI |
InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4) |
| PubChem CID |
62881 |
| Target Point |
Amyloid-β;Ferroptosis |
| Passage |
Neuronal Signaling |
| Background |
Deferoxamine mesylate is the mesylate salt of Deferoxamine, an iron chelator. Deferoxamine is an inhibitor of ferroptosis. Deferoxamine reduces beta-amyloid (Aβ) deposition and induces autophagy. |
| Biological Activity |
Deferoxamine mesylate (Ba 33112， Desferrioxamine B， DFOM， NSC 644468)是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。[1-3] |
| In Vitro |
Deferoxamine mesylate，the iron chelator and ferroptosis inhibitor，rescues neutrophil death induced by systemic lupus erythematosus(SLE)serum，suggesting that ferroptosis may be the main form of neutrophil death in SLE.[3] |
| Animal Experiment |
A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously，the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days.[2] |
| Data Literature Source |
[1] Chuang Guo，et al. Front Aging Neurosci . 2015 Jun 2;7:104.
[2] Xue Yao，et al. Neural Regen Res . 2019 Mar;14(3):532-541.
[3] Li P，et al. Nat Immunol. 2021 Sep;22(9):1107-1117. |
| Unit |
Bottle |
| Specification |
50mg |
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