Anti-CHCHD2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CHCHD2

Immunogen :

Recombinant protein of human CHCHD2

Synonym :

CHCHD2;C7orf17;MNRR1;NS2TP;PARK22;coiled-coil-helix-coiled-coil-helix domain containing 2

Isotype :

IgG

Gene ID :

51142

Clone No :

Swiss Port :

Q9Y6H1

Molecular weight :

16kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC1:100-300.

Subcellular location :

Cytoplasm?Nucleus

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.